protein kinase a gene

Nat Genet 37, 590–592 (2005). Research suggests that these mutations alter the activity of AMP-activated protein kinase in the heart, disrupting the enzyme's ability to respond to changes in cellular energy demands. Replacing the N-terminal serine with alanine does not change Po, but does reduce by about 60% the probability of finding functioning channels. It does not contain a PKA substrate or pseudosubstrate sequence.


Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. One of the fundamental characteristics of SK channels in principle cells and in the TAL is their activation by Gs-coupled receptors or by the addition of cAMP (206). Isoform 2 is sperm-specific and is enriched in pachytene spermatocytes but is not detected in round spermatids.

Among its related pathways are Adenylate cyclase inhibitory pathway and DAG and IP3 signaling.

Wang, T.L. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL:, URL:, URL:, URL:, URL:, URL:, URL:, URL:, URL:, URL:, Learning and Memory: A Comprehensive Reference, 2008, International Review of Cell and Molecular Biology, Dalton and Dewey, 2006; Olsen and Uhler, 1991; Scott et al., 1985; Wen et al., 1994, Cohen et al., 2004; Razani and Lisanti, 2001; Razani et al., 1999, Chaturvedi et al., 2006; Frodin and Gammeltoft, 1999; Gao and Patel, 2009; Gao et al., 2010, Jacobs and Harrison, 1998; Sun and Andersson, 2002, Razani and Lisanti, 2001; Razani et al., 1999, The Molecular Biology of Renal Potassium Channels, Seldin and Giebisch's The Kidney (Fourth Edition), Cellular Physiology of Gastrointestinal Smooth Muscle, Gabriel M. Makhlouf, Karnam S. Murthy, in, Physiology of the Gastrointestinal Tract (Fourth Edition), Christopher Pittenger, ... Christopher Pittenger, in, Progress in Molecular Biology and Translational Science, New Insights into the Mechanism of Wnt Signaling Pathway Activation, Biochemical and Biophysical Research Communications, Interacts with N-terminus of C subunit; anchors C subunit in nucleus; enhances NF-κB p65 phosphorylation by PKA (, Binds to and bocks ATP-binding site; prevents NF-κB p65 phosphorylation by PKA (, PKA binding mechanism unknown; prevents nuclear localization of C subunits (, Contains PKA pseudosubstrate that binds to C subunit substrate-binding pocket; inhibits PKA activity; exports C subunits from nucleus; PKI peptide used as pharmacological PKA inhibitor (, Binds to C-terminus of free catalytic subunits via an N-terminal PKA pseudosubstrate domain; inhibits PKA activity (, Scaffolding domain and C-terminus of Caveolin-1 bind C subunits; Inhibits PKA activity; required for PKA phosphorylation of Perilipin (, RSK1 (active) p90 ribosomal S6 kinase-1 (p90RSK-1), Inactive RSK1 binds to RI and facilitates C subunit release, active RSK1 binds to C subunits and promotes PKA holoenzyme formation (. Phosphopeptide analysis and mapping have shown three serine residues phosphorylated by PKA (one residue on the N terminus [serine 25 in ROMK2] and two residues on the C terminus [serine 200 and serine 294 in ROMK2]).

Further, a specific PKA phosphorylation of LRP6 at Thr1548 enhances the binding of Gαs to LRP6, its localization to the plasma membrane, and the production of cAMP in response to PTH (Wan et al., 2011).
activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase The DMPK gene provides instructions for making a protein called myotonic dystrophy protein kinase.

Similar findings regarding the role of PKA and PKC in acute tolerance to the antinociceptive effect of peripherally administered morphine were reported in the bradykinin-induced flinching test.48 Calphostin C, an inhibitor of PKC, prevented morphine-induced tolerance, whereas KT-5720, an inhibitor of PKA, did not.

Genetics Home Reference content now can be found in the "Genetics" section of MedlinePlus. Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.

et al. NF-κB is a dimer consisting of the p50 and p65 subunits. A Specific Protein Kinase (PK) Gene Is Speculated To Be Differentially Spliced In Muscle Tissue.

These channels, which transport positively charged atoms (ions) into and out of heart muscle cells, play critical roles in maintaining the heart's normal rhythm. However, PKA modulation was recovered for this mutant during concurrent PKC activation, suggesting that PKA phosphorylation may be recruited at one or more additional sites in these circumstances. Thus, PKA and PKG can inhibit sustained contraction by acting on several targets in the RhoA pathway, including the most proximal target, RhoA.

*Please note that Tocris will only send literature to established scientific business / institute addresses. Protein kinase A (PKA)–dependent phosphorylation processes activated by receptor-mediated events or alterations in cytosolic second messengers (e.g., cyclic AMP [cAMP]) play important roles in regulating the native SK channel in principle cells of the CCD (Fig. We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. Protein kinase cGMP dependent type II gene (PRKG2) mutants affect cyclic guanosine monophosphate (cGMP) dependentprotein kinase II (cGKII) protein synthesis and reduce its function.
One is a classical mechanism in which PKA activity is regulated by a small second messenger, cAMP; the other is a novel mechanism in which PKA activity is regulated by a protein, Misty somites. Mutation of any single PKA phosphorylation site on ROMK2 reduces whole-cell K+ currents by 35% to 40% in oocytes; mutation of two or more of the three sites produces nonfunctional channels (220). In the meantime, to ensure continued support, we are displaying the site without styles

For example, it is known that the sharpness of PKA activation is increased by the presence of an inhibitor molecule, which stoichiometrically blocks the kinase until all the inhibitor is bound. The protein may be involved in communication within cells. PKA phosphorylates proteins that have the motif Arginine-Arginine-X-Serine exposed, in turn (de)activating the proteins. The effectiveness of blocking targets downstream of RhoA depends on their relative sensitivity to phosphorylation by PKA or PKG. PGE signaling stabilizes β-catenin by two mechanisms: one is to regulate Axin to release GSK-3 from β-catenin and another to activate Akt leading to phosphorylation and inhibition of GSK-3.

Modulation at this negative membrane potential was recovered following concurrent activation of PKC.

Active Hippo signaling also suppresses the nuclear retention of Yap, which synergistically activates gene expressions with β-catenin in cardiomyogenesis. Wang and coworkers have shown that ROMK1 channels expressed in X. laevis oocytes could not be activated by cAMP unless expressed with A kinase anchoring protein (AKAP) (4).

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